A recent report of detrimental effects on the liver and mediators of inflammation purportedly caused by HCA are refuted in this recent Letter to the Editor published in the World Journal of Gastroenterology.
Garcinia cambogia extract (GC) with its active component consisting of hydroxycitric acid (HCA) is widely utilized for weight loss. Various HCA salts are available, including calcium, magnesium, potassium and mixtures of these. Experimentally, these salts exhibit different properties with some, but not all, improving glucose tolerance and blood pressure. Recently, obesity-prone C57BL/6J mice were fed a high-fat diet (HFD, 45 kcal% fat) with or without GC (1%, w/w) for 16 wk. The ac- tive arm reduced visceral fat, adipocyte size and serum glucose, yet purportedly also exhibited hepatic col- lagen accumulation, lipid peroxidation and increased mRNA levels of genes related to oxidative stress. The latter findings are at odds with a large body of animal and human studies that have been conducted on the safety and efficacy of HCA. This literature shows HCA to be protective against the liver toxicity associated with ethanol and dexamethasone administration, and to maintain serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase at near been found to reduce markers of inflammation in brain, intestines, kidney and serum.
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Citation: Clouatre D and Preuss H. Hydroxycitric acid does not promote inflammation or liver toxicity. World J Gastroenterol 2013 November 28; 19(44): 8160-8162.